Upper GI complications (perforations, ulcers or bleedings); fluid retention & edema; renal toxicity; severe hepatic reactions including fulminant hepatitis, liver necrosis & hepatic failure. Not a substitute for ASA for prophylaxis of CV thromboembolic diseases. Patients w/ CV events (eg, HTN, hyperlipidaemia, DM); preexisting edema, onset of new or worsening of existing HTN; known to be CYP2C9 poor metabolisers; history of GI disease, cardiac failure, left ventricular dysfunction or HTN; galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption; smoking. Discontinue at the 1st sign of skin rash, mucosal lesions or other signs of hypersensitivity. Avoid concomitant use w/ non-aspirin NSAID & warfarin. Mild or moderate renal impairment. Monitor patients w/ impaired renal, heart & liver function. May mask fever & other signs of inflammation. May affect ability to drive or operate machinery. Not to be used during lactation. Not indicated for childn. Elderly (<50 kg).